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Jennifer Bannan

Zer0 to 5ive, LLC

412-580-3675

Frequently Asked Questions...

Is sorbent therapy new?

Sorbent technology was developed from a NASA funded project for removing toxins from waste water for the space program. It has a 35-year history and is backed by over six million treatments. Sorbent cartridges have been recently redesigned and can now regenerate dialysate at flow rates of up to 400 ml/min (SORB™ + cartridges) and for treatment times as long as 8 hours (SORB™ HD cartridges).

What is the quality of the dialysate produced by sorbent cartridges?

Sorbent cartridges provide near ultrapure dialysate (< 1 cfu/ml and < 0.3 EU/ml), exceeding ANSI/AMMI standards and conventional single-pass technology.

Sorbent cartridges have been shown to increasingly purify dialysate throughout a treatment, resulting in near ultrapure final dialysate with mean bacterial levels of < 1cfu/ml and endotoxin levels < 0.3 EU/ml. These levels exceed AMMI/ANSI and ISO standards for dialysate purity. The sorbent cartridge provides near ultrapure final dialysate, not dialysate made with ultrapure water as is defined as a highly desirable standard.

Following is a summary table highlighting the purity of the dialysate:

Contaminant	AMMI/ANSI Standard	Sorbent Cartridge	Ultrapure Standard
Bacterial Cell Count	200 CFU per ml	< 1 CFU per ml	0.1 CFU per ml
Endotoxin Level	2 EU per ml	0.3 EU per ml	.03 EU per ml
Patient Dialysate Volume Exposure/4 hour Tx	120 Liters	6 Liters	NA

Is clearance sacrificed with sorbent therapy because of the small volume of dialysate that is available?

While the volume relationship is an important safety advantage for sorbent therapy, each 6-liter bath provides the equivalent of 100 liters or more of highly pure dialysate that is tailored to the patient’s individual situation and provides the clearances needed without requiring high blood flows to make up for low dialysate flows. What this means clinically is that at the same dialysate and blood flow rate and with the same dialyzer, sorbent dialysis will produce the same efficiency of dialysis as any standard single-pass hemodialysis system.

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